Regulation of mitotic clonal expansion and thermogenic pathway are involved in the antiadipogenic effects of cyanidin-3-O-glucoside

Introduction: Obesity is a metabolic disease with an increase both in cell size (hypertrophy) and number (hyperplasia) following differentiation of new adipocytes. Adipogenesis well-orchestrated program which mitotic clonal expansion (MCE) occurs the early step followed by late terminal one. Methods: Aim study was to evaluate vitro effects cyanidin-3-O-glucoside (C3G), anthocyanin present many fruits vegetables, or phase 3T3-L1 preadipocytes differentiation. Results: C3G exposure adipogenesis process induced more marked reduction CCAAT/enhancer-binding protein-β (C/EBPβ), peroxisome proliferator-activated receptor γ (PPAR-ɣ) fatty acid synthase (Fasn) expression than these were associated reduced MCE cycle arrest at G0/G1 via p21 expression. Furthermore, during activated AMP-activated protein kinase (AMPK) pathway better promoting enhancement beige-like In fact, thermogenic biomarkers uncoupling protein-1 ( Ucp1 ) receptor-gamma coactivator-1 alpha Pgc1 evident exposure. Conclusion: Our data demonstrate that reduces adipogenic affecting inducing program.